SEMA5A

Entrez Summary: This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010].
UniProt Summary: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sema
TSP 1

signal clustering
chondroitin sulfate proteoglycan binding
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
syndecan binding
positive regulation of axon extension involved in axon guidance
positive regulation of axon guidance
positive regulation of actin filament depolymerization
positive regulation of endothelial cell chemotaxis
heparan sulfate proteoglycan binding
positive regulation of protein depolymerization
regulation of endothelial cell chemotaxis
semaphorin receptor binding
endothelial cell proliferation
axonal fasciculation
neuron projection fasciculation
negative regulation of axon extension involved in axon guidance
chemorepellent activity
negative regulation of axon guidance
negative regulation of endothelial cell apoptotic process
regulation of axon extension involved in axon guidance
axon extension
positive regulation of protein complex disassembly
semaphorin-plexin signaling pathway
negative regulation of epithelial cell apoptotic process
negative regulation of axon extension
positive regulation of axon extension
regulation of axon guidance
negative chemotaxis
positive chemotaxis
neuron recognition
regulation of endothelial cell apoptotic process
regulation of actin filament depolymerization
neural crest cell migration
sprouting angiogenesis
negative regulation of chemotaxis
neuron projection extension
negative regulation of axonogenesis
diencephalon development
regulation of epithelial cell apoptotic process
neural crest cell development