SEMG1
Gene Information
- Official Symbol: SEMG1
- Official Name: semenogelin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6406
- UniProt: P04279
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Semenogelin |
GO Terms
| positive regulation of serine-type endopeptidase activity |
| positive regulation of serine-type peptidase activity |
| negative regulation of cilium-dependent cell motility |
| negative regulation of flagellated sperm motility |
| negative regulation of calcium ion import |
| regulation of serine-type peptidase activity |
| regulation of serine-type endopeptidase activity |
| insemination |
| copulation |
| regulation of flagellated sperm motility |
| regulation of cilium-dependent cell motility |
| sperm capacitation |
| mating |
| antibacterial humoral response |
| regulation of calcium ion import |
| killing of cells of other organism |
| disruption of cells of other organism |
| negative regulation of reproductive process |
| negative regulation of calcium ion transport |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| cell killing |
| protein heterooligomerization |
| antimicrobial humoral response |
| negative regulation of ion transport |
| spermatid development |
| modification of morphology or physiology of other organism |
| spermatid differentiation |
| cell maturation |
| regulation of reproductive process |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| multi-multicellular organism process |
| developmental maturation |
| regulation of calcium ion transport |
| germ cell development |
| negative regulation of cell motility |
| coagulation |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| defense response to bacterium |
| humoral immune response |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of proteolysis |
| regulation of metal ion transport |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of transport |
| protein complex oligomerization |
| spermatogenesis |
| male gamete generation |
| protein-containing complex |
| developmental process involved in reproduction |
| response to bacterium |
| gamete generation |
| regulation of ion transport |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| regulation of cell motility |
| defense response to other organism |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| protein-containing complex assembly |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| cell development |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rifampicin 1μM R00 exp31 | 1.72 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.464 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7901
- Expression level (log2 read counts): -7.68
Expression Distribution
SEMG1 Expression in NALM6 Cells: -7.68
