SEPT6

Entrez Summary: N/A
UniProt Summary: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

septin collar
sperm annulus
septin ring
septin complex
axon terminus
cleavage furrow
mitotic cytokinesis
condensed chromosome kinetochore
cytoskeleton-dependent cytokinesis
cytokinesis
synaptic vesicle
spindle
microtubule cytoskeleton
midbody
GTPase activity
cilium assembly
cilium organization
GTP binding
plasma membrane bounded cell projection assembly
cell projection assembly
cell division
spermatogenesis
male gamete generation
mitotic cell cycle process
mitotic cell cycle
gamete generation
viral process
organelle assembly
symbiotic process
interspecies interaction between organisms
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
plasma membrane bounded cell projection organization
cell projection organization
cell cycle
reproductive process
reproduction