SERPINB13

Entrez Summary: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017].
UniProt Summary: May play a role in the proliferation or differentiation of keratinocytes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.93
Thimerosal 0.85μM R08 exp529	-1.7
BI-2536 0.001μM R01 exp41	1.77

negative regulation of keratinocyte apoptotic process
regulation of keratinocyte apoptotic process
cysteine-type endopeptidase inhibitor activity
regulation of keratinocyte differentiation
negative regulation of epithelial cell apoptotic process
regulation of epidermal cell differentiation
regulation of epithelial cell apoptotic process
regulation of epidermis development
lysosomal lumen
serine-type endopeptidase inhibitor activity
protease binding
regulation of epithelial cell differentiation
response to UV
negative regulation of endopeptidase activity
negative regulation of peptidase activity
response to light stimulus
negative regulation of proteolysis
nuclear speck
regulation of endopeptidase activity
response to radiation
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
nucleolus
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
response to abiotic stimulus
regulation of hydrolase activity
regulation of apoptotic process
regulation of programmed cell death
extracellular space
regulation of cell death
regulation of cell differentiation