SERPINF2
Gene Information
- Official Symbol: SERPINF2
- Official Name: serpin family F member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5345
- UniProt: P08697
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
- UniProt Summary: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}.
Pfam Domains GO Terms
Pfam Domains
| Serpin |
GO Terms
| regulation of blood vessel diameter by renin-angiotensin |
| renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure |
| negative regulation of plasminogen activation |
| fibrinogen complex |
| negative regulation of fibrinolysis |
| positive regulation of cell-cell adhesion mediated by cadherin |
| regulation of plasminogen activation |
| regulation of fibrinolysis |
| regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of transforming growth factor beta production |
| fibrinolysis |
| regulation of systemic arterial blood pressure by renin-angiotensin |
| renal system process involved in regulation of systemic arterial blood pressure |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| positive regulation of hemostasis |
| positive regulation of blood coagulation |
| positive regulation of coagulation |
| negative regulation of protein processing |
| negative regulation of protein maturation |
| endopeptidase inhibitor activity |
| regulation of collagen biosynthetic process |
| regulation of transforming growth factor beta production |
| regulation of systemic arterial blood pressure by hormone |
| acute-phase response |
| regulation of collagen metabolic process |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| collagen fibril organization |
| endocrine process |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| positive regulation of stress fiber assembly |
| negative regulation of coagulation |
| positive regulation of wound healing |
| positive regulation of actin filament bundle assembly |
| positive regulation of response to wounding |
| regulation of protein processing |
| platelet alpha granule lumen |
| regulation of protein maturation |
| acute inflammatory response |
| negative regulation of wound healing |
| regulation of stress fiber assembly |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| positive regulation of smooth muscle cell proliferation |
| negative regulation of response to wounding |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| regulation of systemic arterial blood pressure |
| serine-type endopeptidase inhibitor activity |
| protease binding |
| renal system process |
| platelet degranulation |
| regulation of smooth muscle cell proliferation |
| regulation of wound healing |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| positive regulation of JNK cascade |
| regulation of tube size |
| blood microparticle |
| regulation of response to wounding |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| vascular process in circulatory system |
| regulation of blood pressure |
| regulation of JNK cascade |
| positive regulation of supramolecular fiber organization |
| positive regulation of ERK1 and ERK2 cascade |
| positive regulation of cytoskeleton organization |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of endopeptidase activity |
| positive regulation of cell-cell adhesion |
| negative regulation of peptidase activity |
| regulation of actin filament organization |
| regulation of ERK1 and ERK2 cascade |
| extracellular matrix organization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of proteolysis |
| collagen-containing extracellular matrix |
| negative regulation of response to external stimulus |
| extracellular structure organization |
| regulation of actin filament-based process |
| blood circulation |
| circulatory system process |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| blood vessel morphogenesis |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| supramolecular fiber organization |
| blood vessel development |
| regulation of body fluid levels |
| inflammatory response |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of MAPK cascade |
| positive regulation of response to external stimulus |
| cell surface |
| positive regulation of organelle organization |
| tube morphogenesis |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulated exocytosis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| exocytosis |
| tube development |
| circulatory system development |
| protein homodimerization activity |
| positive regulation of cell population proliferation |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| defense response |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9341
- Expression level (log2 read counts): -0.87
Expression Distribution
SERPINF2 Expression in NALM6 Cells: -0.87
