SERPINH1

Entrez Summary: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011].
UniProt Summary: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen biosynthetic process
chondrocyte development involved in endochondral bone morphogenesis
chondrocyte differentiation involved in endochondral bone morphogenesis
chondrocyte development
cartilage development involved in endochondral bone morphogenesis
collagen fibril organization
collagen binding
collagen metabolic process
endochondral bone morphogenesis
endoplasmic reticulum-Golgi intermediate compartment
chondrocyte differentiation
serine-type endopeptidase inhibitor activity
bone morphogenesis
unfolded protein binding
response to unfolded protein
cartilage development
response to topologically incorrect protein
bone development
connective tissue development
membrane raft
protein maturation
skeletal system morphogenesis
negative regulation of endopeptidase activity
negative regulation of peptidase activity
endoplasmic reticulum lumen
extracellular matrix organization
negative regulation of proteolysis
collagen-containing extracellular matrix
extracellular structure organization
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
supramolecular fiber organization
skeletal system development
regulation of proteolysis
negative regulation of catalytic activity
animal organ morphogenesis
endoplasmic reticulum
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process