SF3B14

Gene Information
  • Official Symbol: N/A
  • Official Name: N/A
  • Aliases and Previous Symbols: N/A
  • Entrez ID: N/A
  • UniProt: N/A
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: N/A
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16432215, ECO:0000269|PubMed:27720643}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2885
  • Expression level (log2 read counts): N/A

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1