SF3B3 [The Human Chemical-Genetic Interaction Map Project]

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======= SF3B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SF3B3
  * **<color #00a2e8>Official Name</color>**: splicing factor 3b subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23450|23450]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15393|Q15393]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SF3B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SF3B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605592|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CPSF A|
|MMS1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U12-type spliceosomal complex|
|U2-type precatalytic spliceosome|
|catalytic step 2 spliceosome|
|negative regulation of protein catabolic process|
|nucleic acid binding|
|protein-containing complex binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|regulation of catabolic process|
|negative regulation of protein metabolic process|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-3.18|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.24|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.85|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.85|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.83|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.75|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.76|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.77|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.78|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.8|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.84|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.89|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.92|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.13|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.27|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.37|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.38|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.39|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.45|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.463|
|[[:human genes:c:c14orf93|C14orf93]]|0.447|
|[[:human genes:r:rps2|RPS2]]|0.434|
|[[:human genes:p:prim1|PRIM1]]|0.433|
|[[:human genes:a:ahctf1|AHCTF1]]|0.43|
|[[:human genes:p:pan3|PAN3]]|0.426|
|[[:human genes:z:znf513|ZNF513]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.422|
|[[:human genes:p:psmd3|PSMD3]]|0.421|
|[[:human genes:p:pan2|PAN2]]|0.421|
|[[:human genes:n:npipb5|NPIPB5]]|0.417|
|[[:human genes:n:nup155|NUP155]]|0.411|
|[[:human genes:m:mtch2|MTCH2]]|0.41|
|[[:human genes:k:kif3c|KIF3C]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 79
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SF3B3 Expression in NALM6 Cells: 8.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>