SFTPA2

Entrez Summary: This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lectin C
Collagen

lamellar body
surfactant homeostasis
chemical homeostasis within a tissue
monosaccharide binding
clathrin-coated endocytic vesicle
multivesicular body
lipopolysaccharide binding
respiratory gaseous exchange by respiratory system
rough endoplasmic reticulum
collagen trimer
positive regulation of phagocytosis
regulation of phagocytosis
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
tissue homeostasis
innate immune response-activating signal transduction
activation of innate immune response
multicellular organismal homeostasis
positive regulation of innate immune response
anatomical structure homeostasis
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
regulation of vesicle-mediated transport
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
endoplasmic reticulum membrane
positive regulation of transport
regulation of response to external stimulus
chemical homeostasis
regulation of immune response
positive regulation of immune system process
regulation of response to stress