SFTPD

Gene Information

Official Symbol: SFTPD
Official Name: surfactant protein D
Aliases and Previous Symbols: N/A
Entrez ID: 6441
UniProt: P35247
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015].
UniProt Summary: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269|PubMed:23478426}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4679
Expression level (log2 read counts): -7.68

Expression Distribution

Lectin C
Collagen
Surfac D-trimer

regulation of adhesion of symbiont to host epithelial cell
negative regulation of interleukin-2 biosynthetic process
negative regulation by host of symbiont molecular function
induction of bacterial agglutination
modulation by host of symbiont molecular function
negative regulation of molecular function in other organism
negative regulation of molecular function in other organism involved in symbiotic interaction
modulation of molecular function in other organism
modulation of molecular function in other organism involved in symbiotic interaction
surfactant homeostasis
chemical homeostasis within a tissue
macrophage chemotaxis
monosaccharide binding
regulation of interleukin-2 biosynthetic process
macrophage migration
negative regulation of interleukin-2 production
clathrin-coated endocytic vesicle
negative regulation of cytokine biosynthetic process
multivesicular body
lipopolysaccharide binding
antibacterial humoral response
lung alveolus development
respiratory gaseous exchange by respiratory system
regulation of interleukin-2 production
endocytic vesicle
negative regulation of T cell proliferation
rough endoplasmic reticulum
collagen trimer
positive regulation of phagocytosis
modification by host of symbiont morphology or physiology
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
interaction with symbiont
negative regulation of leukocyte proliferation
regulation of phagocytosis
toll-like receptor signaling pathway
regulation of cytokine biosynthetic process
negative regulation of T cell activation
modification of morphology or physiology of other organism involved in symbiotic interaction
antimicrobial humoral response