SFXN1 [The Human Chemical-Genetic Interaction Map Project]

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======= SFXN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFXN1
  * **<color #00a2e8>Official Name</color>**: sideroflexin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94081|94081]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9B4|Q9H9B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFXN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFXN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mtc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D-serine transmembrane transporter activity|
|serine import into mitochondrion|
|D-serine transport|
|L-serine transport|
|L-serine transmembrane transporter activity|
|D-amino acid transport|
|serine transport|
|amino acid import|
|one-carbon metabolic process|
|integral component of mitochondrial inner membrane|
|neutral amino acid transport|
|L-amino acid transport|
|iron ion transport|
|amino acid transmembrane transport|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|mitochondrial transmembrane transport|
|myeloid cell homeostasis|
|amino acid transport|
|transition metal ion transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|homeostasis of number of cells|
|mitochondrial transport|
|myeloid cell differentiation|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|organic anion transport|
|hemopoiesis|
|anion transport|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion transport|
|immune system development|
|cation transport|
|ion transmembrane transport|
|response to drug|
|mitochondrion|
|transmembrane transport|
|ion transport|
|homeostatic process|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.44|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.72|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.75|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.84|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.92|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.03|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.27|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.439|
|[[:human genes:s:slc25a32|SLC25A32]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFXN1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>