SGCD

Entrez Summary: The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sarcoglycan complex
coronary vasculature morphogenesis
dystrophin-associated glycoprotein complex
cardiac muscle fiber development
cellular protein-containing complex localization
cardiac muscle cell contraction
sarcoplasmic reticulum
coronary vasculature development
muscle fiber development
cardiac muscle cell development
cardiac cell development
cardiac muscle contraction
heart contraction
cardiac muscle cell differentiation
actin-mediated cell contraction
sarcolemma
heart process
striated muscle contraction
actin filament-based movement
cardiocyte differentiation
striated muscle cell development
calcium-mediated signaling
muscle cell development
cardiac muscle tissue development
striated muscle cell differentiation
muscle cell differentiation
muscle contraction
protein-containing complex localization
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
second-messenger-mediated signaling
cytoskeleton
blood circulation
circulatory system process
blood vessel morphogenesis
calcium ion homeostasis
muscle structure development
blood vessel development