SH2B3

Gene Information

Official Symbol: SH2B3
Official Name: SH2B adaptor protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 10019
UniProt: Q9UQQ2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
UniProt Summary: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8544
Expression level (log2 read counts): 5.14

Expression Distribution

Screen	Score
Tanespimycin 14μM R08 exp527	-1.83
TRAIL 50ng/ml R00 exp36	1.75

SH2
Phe ZIP
PH

regulation of Kit signaling pathway
monocyte homeostasis
negative regulation of Kit signaling pathway
stem cell factor receptor binding
thrombopoietin-mediated signaling pathway
response to interleukin-3
cellular response to interleukin-3
negative regulation of chemokine-mediated signaling pathway
regulation of chemokine-mediated signaling pathway
neutrophil homeostasis
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of platelet aggregation
transmembrane receptor protein tyrosine kinase adaptor activity
negative regulation of homotypic cell-cell adhesion
megakaryocyte development
regulation of platelet aggregation
negative regulation of platelet activation
negative regulation of receptor signaling pathway via JAK-STAT
embryonic hemopoiesis
negative regulation of receptor signaling pathway via STAT
megakaryocyte differentiation
bone cell development
regulation of homotypic cell-cell adhesion
protein tyrosine kinase binding
regulation of platelet activation
erythrocyte development
negative regulation of protein kinase B signaling
negative regulation of blood coagulation
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of hemostasis
negative regulation of coagulation
SH3/SH2 adaptor activity
myeloid cell development
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
leukocyte homeostasis
negative regulation of wound healing
negative regulation of MAP kinase activity
regulation of blood coagulation
regulation of tyrosine phosphorylation of STAT protein