SH3PXD2A

Entrez Summary: N/A
UniProt Summary: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

osteoclast fusion
multinuclear osteoclast differentiation
superoxide-generating NADPH oxidase activator activity
phosphatidylinositol-5-phosphate binding
podosome
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-3,4-bisphosphate binding
cell-cell fusion
syncytium formation by plasma membrane fusion
syncytium formation
superoxide metabolic process
phosphatidylinositol-3-phosphate binding
osteoclast differentiation
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol binding
cell projection
protease binding
myeloid leukocyte differentiation
reactive oxygen species metabolic process
myeloid cell differentiation
leukocyte differentiation
extracellular matrix organization
in utero embryonic development
extracellular structure organization
cell junction
hemopoiesis
hematopoietic or lymphoid organ development
chordate embryonic development
immune system development
embryo development ending in birth or egg hatching
anatomical structure formation involved in morphogenesis
embryo development
positive regulation of catalytic activity
positive regulation of molecular function