SH3RF1

Gene Information

Official Symbol: SH3RF1
Official Name: SH3 domain containing ring finger 1
Aliases and Previous Symbols: N/A
Entrez ID: 57630
UniProt: Q7Z6J0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010}. Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18077
Expression level (log2 read counts): 3.21

Expression Distribution

SH3 1
SH3 2
zf-C3HC4

regulation of CD8-positive, alpha-beta T cell proliferation
MAP-kinase scaffold activity
regulation of CD8-positive, alpha-beta T cell activation
regulation of alpha-beta T cell proliferation
regulation of CD4-positive, alpha-beta T cell differentiation
regulation of CD4-positive, alpha-beta T cell activation
regulation of alpha-beta T cell differentiation
protein autoubiquitination
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
regulation of alpha-beta T cell activation
negative regulation of extrinsic apoptotic signaling pathway
neuron migration
regulation of T cell differentiation
positive regulation of JNK cascade
regulation of extrinsic apoptotic signaling pathway
regulation of T cell proliferation
positive regulation of stress-activated MAPK cascade
regulation of lymphocyte differentiation
positive regulation of stress-activated protein kinase signaling cascade
lamellipodium
regulation of JNK cascade
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ubiquitin protein ligase activity
regulation of leukocyte proliferation
negative regulation of apoptotic signaling pathway
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
regulation of leukocyte differentiation
regulation of T cell activation
negative regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
regulation of hemopoiesis