SHC3

Entrez Summary: N/A
UniProt Summary: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH2
PID

synaptic transmission, glutamatergic
phosphotyrosine residue binding
epidermal growth factor receptor signaling pathway
receptor tyrosine kinase binding
ERBB signaling pathway
Ras protein signal transduction
learning or memory
axon guidance
neuron projection guidance
cognition
small GTPase mediated signal transduction
MAPK cascade
axonogenesis
signal transduction by protein phosphorylation
axon development
anterograde trans-synaptic signaling
chemical synaptic transmission
cell morphogenesis involved in neuron differentiation
trans-synaptic signaling
cellular component
synaptic signaling
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
behavior
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
protein phosphorylation
central nervous system development
neuron differentiation
cell-cell signaling
plasma membrane bounded cell projection organization