SHISA5

Entrez Summary: This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016].
UniProt Summary: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:12135983}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage
signal transduction by p53 class mediator
intrinsic apoptotic signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling
nuclear membrane
apoptotic signaling pathway
endoplasmic reticulum lumen
post-translational protein modification
cellular response to DNA damage stimulus
apoptotic process
endoplasmic reticulum membrane
endoplasmic reticulum
positive regulation of intracellular signal transduction
programmed cell death
cell death
positive regulation of signal transduction
intracellular signal transduction
cellular response to stress
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction