SIGMAR1

Entrez Summary: This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell death in response to hydrogen peroxide
opioid receptor activity
opioid receptor signaling pathway
cell death in response to oxidative stress
nuclear outer membrane
protein homotrimerization
nuclear inner membrane
protein trimerization
drug binding
cellular response to hydrogen peroxide
lipid droplet
cellular response to antibiotic
response to hydrogen peroxide
growth cone
cellular response to reactive oxygen species
nuclear envelope
response to reactive oxygen species
postsynaptic membrane
regulation of neuron apoptotic process
cellular response to toxic substance
cellular response to oxidative stress
postsynaptic density
cytoplasmic vesicle
lipid transport
response to antibiotic
regulation of neuron death
lipid localization
protein homooligomerization
response to oxidative stress
cellular response to drug
response to toxic substance
protein complex oligomerization
response to inorganic substance
cell junction
endoplasmic reticulum membrane
endoplasmic reticulum
response to drug
cellular response to oxygen-containing compound
cell death
G protein-coupled receptor signaling pathway