SIPA1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= SIPA1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIPA1L1
  * **<color #00a2e8>Official Name</color>**: signal induced proliferation associated 1 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26037|26037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43166|O43166]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIPA1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIPA1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3401|
|Rap GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ephrin receptor binding|
|regulation of dendritic spine morphogenesis|
|actin cytoskeleton reorganization|
|regulation of dendritic spine development|
|ephrin receptor signaling pathway|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|activation of GTPase activity|
|dendritic spine|
|regulation of dendrite development|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|postsynaptic density|
|GTPase activator activity|
|regulation of cell morphogenesis involved in differentiation|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|positive regulation of GTPase activity|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cellular component|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell junction|
|actin filament-based process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|molecular function|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|generation of neurons|
|neurogenesis|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.91|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIPA1L1 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>