SIPA1L1

Entrez Summary: N/A
UniProt Summary: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BS-181 20μM R08 exp461	1.91
ABT-702 5μM R06 exp261	1.99

DUF3401
Rap GAP

ephrin receptor binding
regulation of dendritic spine morphogenesis
actin cytoskeleton reorganization
regulation of dendritic spine development
ephrin receptor signaling pathway
regulation of dendrite morphogenesis
regulation of postsynapse organization
activation of GTPase activity
dendritic spine
regulation of dendrite development
regulation of axonogenesis
regulation of synaptic plasticity
postsynaptic membrane
regulation of synapse organization
regulation of synapse structure or activity
postsynaptic density
GTPase activator activity
regulation of cell morphogenesis involved in differentiation
regulation of small GTPase mediated signal transduction
cytoskeleton
positive regulation of GTPase activity
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
cellular component
regulation of GTPase activity
regulation of cell morphogenesis
actin cytoskeleton organization
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
cell junction
actin filament-based process
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
enzyme linked receptor protein signaling pathway
molecular function
positive regulation of hydrolase activity
regulation of neurogenesis
regulation of nervous system development
regulation of cell development