SIRPA [The Human Chemical-Genetic Interaction Map Project]

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======= SIRPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIRPA
  * **<color #00a2e8>Official Name</color>**: signal regulatory protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140885|140885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78324|P78324]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIRPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIRPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|V-set|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of I-kappaB phosphorylation|
|negative regulation of macrophage inflammatory protein 1 alpha production|
|negative regulation of chemokine (C-C motif) ligand 5 production|
|monocyte extravasation|
|regulation of I-kappaB phosphorylation|
|regulation of macrophage inflammatory protein 1 alpha production|
|protein binding involved in heterotypic cell-cell adhesion|
|protein antigen binding|
|regulation of chemokine (C-C motif) ligand 5 production|
|negative regulation of nitric oxide metabolic process|
|negative regulation of interferon-beta production|
|negative regulation of nitric oxide biosynthetic process|
|GTPase regulator activity|
|negative regulation of cytokine production involved in inflammatory response|
|negative regulation of chemokine production|
|cell-cell adhesion mediator activity|
|negative regulation of phagocytosis|
|protein tyrosine kinase binding|
|negative regulation of reactive oxygen species biosynthetic process|
|heterotypic cell-cell adhesion|
|negative regulation of JNK cascade|
|cellular extravasation|
|regulation of cytokine production involved in inflammatory response|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of interleukin-6 production|
|negative regulation of type I interferon production|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|regulation of interferon-beta production|
|mononuclear cell migration|
|cellular response to interleukin-12|
|response to interleukin-12|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|negative regulation of tumor necrosis factor production|
|ficolin-1-rich granule membrane|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of phagocytosis|
|cellular response to hydrogen peroxide|
|tertiary granule membrane|
|regulation of chemokine production|
|regulation of interleukin-1 beta production|
|protein phosphatase binding|
|regulation of reactive oxygen species biosynthetic process|
|regulation of interleukin-1 production|
|regulation of phagocytosis|
|regulation of interferon-gamma production|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of type I interferon production|
|myeloid leukocyte migration|
|SH3 domain binding|
|cellular response to reactive oxygen species|
|negative regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to interferon-gamma|
|negative regulation of MAPK cascade|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|response to interleukin-1|
|positive regulation of T cell activation|
|negative regulation of defense response|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|positive regulation of cell-cell adhesion|
|negative regulation of cytokine production|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|leukocyte migration|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|cellular response to drug|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|negative regulation of phosphorylation|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|response to lipid|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIRPA Expression in NALM6 Cells: -0.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>