SIRT5

Entrez Summary: N/A
UniProt Summary: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {ECO:0000250|UniProtKB:Q8K2C6, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062, ECO:0000269|PubMed:24703693}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.11
SNS-032 25μM R07 exp401	1.83

protein-glutaryllysine deglutarylase activity
protein deglutarylation
protein-malonyllysine demalonylase activity
peptidyl-lysine deglutarylation
peptidyl-lysine desuccinylation
peptidyl-lysine demalonylation
protein desuccinylation
protein demalonylation
protein-succinyllysine desuccinylase activity
NAD-dependent protein deacetylase activity
regulation of ketone biosynthetic process
NAD+ binding
negative regulation of cardiac muscle cell apoptotic process
negative regulation of striated muscle cell apoptotic process
NAD+ ADP-ribosyltransferase activity
protein ADP-ribosylation
regulation of cardiac muscle cell apoptotic process
negative regulation of muscle cell apoptotic process
regulation of striated muscle cell apoptotic process
protein deacetylation
negative regulation of reactive oxygen species metabolic process
chromatin organization involved in negative regulation of transcription
chromatin silencing
protein deacylation
macromolecule deacylation
regulation of muscle cell apoptotic process
chromatin organization involved in regulation of transcription
mitochondrial intermembrane space
negative regulation of gene expression, epigenetic
gene silencing
regulation of cellular ketone metabolic process
regulation of reactive oxygen species metabolic process
regulation of gene expression, epigenetic
peptidyl-lysine modification
mitochondrial matrix
mitochondrial inner membrane
regulation of small molecule metabolic process
mitochondrion organization
response to nutrient levels
response to extracellular stimulus