SIRT6 [The Human Chemical-Genetic Interaction Map Project]

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======= SIRT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIRT6
  * **<color #00a2e8>Official Name</color>**: sirtuin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51548|51548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N6T7|Q8N6T7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIRT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIRT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606211|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SIR2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chromatin silencing at telomere|
|post-embryonic cardiac muscle cell growth involved in heart morphogenesis|
|regulation of telomeric heterochromatin assembly|
|positive regulation of telomeric heterochromatin assembly|
|cardiac muscle tissue growth involved in heart morphogenesis|
|NAD-dependent histone deacetylase activity (H3-K9 specific)|
|histone H3-K9 deacetylation|
|regulation of chromatin silencing at telomere|
|nuclear telomeric heterochromatin|
|regulation of heterochromatin assembly|
|positive regulation of heterochromatin assembly|
|positive regulation of chromatin assembly or disassembly|
|positive regulation blood vessel branching|
|growth involved in heart morphogenesis|
|regulation of chromatin assembly|
|NAD-dependent histone deacetylase activity|
|positive regulation of chondrocyte proliferation|
|regulation of blood vessel branching|
|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|
|NAD-dependent protein deacetylase activity|
|regulation of chromatin assembly or disassembly|
|negative regulation of glucose import|
|negative regulation of glycolytic process|
|positive regulation of chromatin silencing|
|positive regulation of vascular endothelial cell proliferation|
|NAD+ binding|
|negative regulation of glucose transmembrane transport|
|negative regulation of purine nucleotide metabolic process|
|histone H3-K9 modification|
|negative regulation of nucleotide metabolic process|
|regulation of vascular endothelial cell proliferation|
|histone H3 deacetylation|
|negative regulation of ATP metabolic process|
|cardiac muscle tissue growth|
|NAD+ ADP-ribosyltransferase activity|
|histone deacetylase activity|
|heart growth|
|protein ADP-ribosylation|
|positive regulation of morphogenesis of an epithelium|
|regulation of chromatin silencing|
|base-excision repair|
|positive regulation of stem cell proliferation|
|negative regulation of cellular carbohydrate metabolic process|
|protein destabilization|
|regulation of double-strand break repair via homologous recombination|
|negative regulation of carbohydrate metabolic process|
|histone deacetylation|
|positive regulation of telomere maintenance|
|positive regulation of fibroblast proliferation|
|protein deacetylation|
|regulation of glucose import|
|regulation of morphogenesis of a branching structure|
|protein deacylation|
|macromolecule deacylation|
|regulation of stem cell proliferation|
|cardiac muscle tissue morphogenesis|
|regulation of glucose transmembrane transport|
|regulation of double-strand break repair|
|regulation of glycolytic process|
|muscle tissue morphogenesis|
|regulation of fibroblast proliferation|
|regulation of telomere maintenance|
|muscle organ morphogenesis|
|regulation of carbohydrate catabolic process|
|developmental cell growth|
|cell growth|
|negative regulation of small molecule metabolic process|
|positive regulation of endothelial cell proliferation|
|organ growth|
|positive regulation of cold-induced thermogenesis|
|regulation of DNA recombination|
|positive regulation of chromatin organization|
|developmental growth involved in morphogenesis|
|negative regulation of transmembrane transport|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|regulation of DNA repair|
|regulation of endothelial cell proliferation|
|regulation of gene silencing|
|regulation of cellular carbohydrate metabolic process|
|regulation of cold-induced thermogenesis|
|regulation of generation of precursor metabolites and energy|
|cardiac muscle tissue development|
|positive regulation of angiogenesis|
|positive regulation of chromosome organization|
|regulation of morphogenesis of an epithelium|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of chromatin organization|
|positive regulation of epithelial cell proliferation|
|positive regulation of DNA metabolic process|
|regulation of carbohydrate metabolic process|
|regulation of response to DNA damage stimulus|
|transcription corepressor activity|
|heart morphogenesis|
|striated muscle tissue development|
|regulation of angiogenesis|
|regulation of protein stability|
|muscle organ development|
|muscle tissue development|
|negative regulation of catabolic process|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|developmental growth|
|growth|
|chromatin binding|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|muscle structure development|
|negative regulation of transport|
|response to nutrient levels|
|DNA repair|
|positive regulation of cellular component biogenesis|
|heart development|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|tissue morphogenesis|
|positive regulation of organelle organization|
|negative regulation of cell population proliferation|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|chemical homeostasis|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|homeostatic process|
|cell development|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.15|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.96|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.09|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.13|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.3|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIRT6 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>