SIRT6
Gene Information
- Official Symbol: SIRT6
- Official Name: sirtuin 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 51548
- UniProt: Q8N6T7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SIR2 |
GO Terms
| positive regulation of chromatin silencing at telomere |
| post-embryonic cardiac muscle cell growth involved in heart morphogenesis |
| regulation of telomeric heterochromatin assembly |
| positive regulation of telomeric heterochromatin assembly |
| cardiac muscle tissue growth involved in heart morphogenesis |
| NAD-dependent histone deacetylase activity (H3-K9 specific) |
| histone H3-K9 deacetylation |
| regulation of chromatin silencing at telomere |
| nuclear telomeric heterochromatin |
| regulation of heterochromatin assembly |
| positive regulation of heterochromatin assembly |
| positive regulation of chromatin assembly or disassembly |
| positive regulation blood vessel branching |
| growth involved in heart morphogenesis |
| regulation of chromatin assembly |
| NAD-dependent histone deacetylase activity |
| positive regulation of chondrocyte proliferation |
| regulation of blood vessel branching |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
| NAD-dependent protein deacetylase activity |
| regulation of chromatin assembly or disassembly |
| negative regulation of glucose import |
| negative regulation of glycolytic process |
| positive regulation of chromatin silencing |
| positive regulation of vascular endothelial cell proliferation |
| NAD+ binding |
| negative regulation of glucose transmembrane transport |
| negative regulation of purine nucleotide metabolic process |
| histone H3-K9 modification |
| negative regulation of nucleotide metabolic process |
| regulation of vascular endothelial cell proliferation |
| histone H3 deacetylation |
| negative regulation of ATP metabolic process |
| cardiac muscle tissue growth |
| NAD+ ADP-ribosyltransferase activity |
| histone deacetylase activity |
| heart growth |
| protein ADP-ribosylation |
| positive regulation of morphogenesis of an epithelium |
| regulation of chromatin silencing |
| base-excision repair |
| positive regulation of stem cell proliferation |
| negative regulation of cellular carbohydrate metabolic process |
| protein destabilization |
| regulation of double-strand break repair via homologous recombination |
| negative regulation of carbohydrate metabolic process |
| histone deacetylation |
| positive regulation of telomere maintenance |
| positive regulation of fibroblast proliferation |
| protein deacetylation |
| regulation of glucose import |
| regulation of morphogenesis of a branching structure |
| protein deacylation |
| macromolecule deacylation |
| regulation of stem cell proliferation |
| cardiac muscle tissue morphogenesis |
| regulation of glucose transmembrane transport |
| regulation of double-strand break repair |
| regulation of glycolytic process |
| muscle tissue morphogenesis |
| regulation of fibroblast proliferation |
| regulation of telomere maintenance |
| muscle organ morphogenesis |
| regulation of carbohydrate catabolic process |
| developmental cell growth |
| cell growth |
| negative regulation of small molecule metabolic process |
| positive regulation of endothelial cell proliferation |
| organ growth |
| positive regulation of cold-induced thermogenesis |
| regulation of DNA recombination |
| positive regulation of chromatin organization |
| developmental growth involved in morphogenesis |
| negative regulation of transmembrane transport |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| regulation of DNA repair |
| regulation of endothelial cell proliferation |
| regulation of gene silencing |
| regulation of cellular carbohydrate metabolic process |
| regulation of cold-induced thermogenesis |
| regulation of generation of precursor metabolites and energy |
| cardiac muscle tissue development |
| positive regulation of angiogenesis |
| positive regulation of chromosome organization |
| regulation of morphogenesis of an epithelium |
| positive regulation of vasculature development |
| glucose homeostasis |
| carbohydrate homeostasis |
| regulation of chromatin organization |
| positive regulation of epithelial cell proliferation |
| positive regulation of DNA metabolic process |
| regulation of carbohydrate metabolic process |
| regulation of response to DNA damage stimulus |
| transcription corepressor activity |
| heart morphogenesis |
| striated muscle tissue development |
| regulation of angiogenesis |
| regulation of protein stability |
| muscle organ development |
| muscle tissue development |
| negative regulation of catabolic process |
| regulation of vasculature development |
| regulation of epithelial cell proliferation |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| histone modification |
| covalent chromatin modification |
| developmental growth |
| growth |
| chromatin binding |
| regulation of small molecule metabolic process |
| negative regulation of phosphorylation |
| muscle structure development |
| negative regulation of transport |
| response to nutrient levels |
| DNA repair |
| positive regulation of cellular component biogenesis |
| heart development |
| response to extracellular stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| tissue morphogenesis |
| positive regulation of organelle organization |
| negative regulation of cell population proliferation |
| chromatin organization |
| regulation of cellular response to stress |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| zinc ion binding |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| regulation of catabolic process |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| chemical homeostasis |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| homeostatic process |
| cell development |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aminopterin 0.005μM R07 exp335 | -2.15 |
| Ethanol 0.01 R05 exp234 | 1.96 |
| Dimethyl-Sulfoxide 1pc R03 exp120 | 2.09 |
| MLN-4924 0.2μM R00 exp21 | 2.13 |
| BI-D1870 2μM R04 exp162 | 2.3 |
| Rapamycin 10μM R00 exp30 | 3.08 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4989
- Expression level (log2 read counts): 4.09
Expression Distribution
SIRT6 Expression in NALM6 Cells: 4.09
