SIX1

Entrez Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox KN
Homeobox

cellular response to 3,3,5-triiodo-L-thyronine
response to 3,3,5-triiodo-L-thyronine
positive regulation of mesenchymal cell proliferation involved in ureter development
myotome development
olfactory placode formation
ureter smooth muscle cell differentiation
olfactory placode morphogenesis
olfactory placode development
positive regulation of secondary heart field cardioblast proliferation
regulation of mesenchymal cell proliferation involved in ureter development
ureter smooth muscle development
regulation of ureteric bud formation
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
positive regulation of epithelial tube formation
regulation of synaptic growth at neuromuscular junction
trigeminal ganglion development
fungiform papilla morphogenesis
fungiform papilla development
cranial ganglion development
mesonephric tubule formation
tongue morphogenesis
regulation of secondary heart field cardioblast proliferation
regulation of cardioblast proliferation
facial nerve morphogenesis
regulation of neuromuscular junction development
ectodermal placode formation
ectodermal placode morphogenesis
facial nerve development
ectodermal placode development
myoblast migration
regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle cell proliferation
metanephric mesenchyme development
otic vesicle development
ureter development
organ induction
nose development
ganglion development
cellular response to thyroid hormone stimulus