SLC12A7

Entrez Summary: N/A
UniProt Summary: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium:chloride symporter activity
chloride ion homeostasis
monovalent inorganic anion homeostasis
cell volume homeostasis
potassium ion homeostasis
potassium ion import across plasma membrane
anion homeostasis
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
chloride transmembrane transport
import across plasma membrane
chloride transport
inorganic anion transmembrane transport
monovalent inorganic cation homeostasis
inorganic anion transport
potassium ion transmembrane transport
potassium ion transport
regulation of cell size
anion transmembrane transport
regulation of cellular component size
monovalent inorganic cation transport
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
protein kinase binding
regulation of anatomical structure size
inorganic cation transmembrane transport
anion transport
protein-containing complex
cation transmembrane transport
metal ion homeostasis
metal ion transport
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
ion homeostasis
cation transport
cellular homeostasis