SLC16A3

Entrez Summary: N/A
UniProt Summary: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plasma membrane lactate transport
lactate transmembrane transporter activity
lactate transmembrane transport
lactate transport
monocarboxylic acid transmembrane transporter activity
parallel fiber to Purkinje cell synapse
symporter activity
integral component of postsynaptic density membrane
pyruvate metabolic process
carboxylic acid transmembrane transport
organic acid transmembrane transport
monocarboxylic acid transport
organic hydroxy compound transport
nuclear membrane
anion transmembrane transport
organic acid transport
carboxylic acid transport
leukocyte migration
organic anion transport
monocarboxylic acid metabolic process
anion transport
carboxylic acid metabolic process
ion transmembrane transport
cell migration
oxoacid metabolic process
organic acid metabolic process
localization of cell
cell motility
transmembrane transport
locomotion
ion transport
RNA binding
integral component of plasma membrane
movement of cell or subcellular component
small molecule metabolic process
membrane