SLC18A1

Entrez Summary: N/A
UniProt Summary: Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. {ECO:0000269|PubMed:16326835, ECO:0000269|PubMed:8643547}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

serotonin:sodium symporter activity
serotonin uptake
aminergic neurotransmitter loading into synaptic vesicle
clathrin-sculpted monoamine transport vesicle membrane
serotonin transport
monoamine transmembrane transporter activity
amine transport
neurotransmitter loading into synaptic vesicle
xenobiotic transmembrane transporter activity
neurotransmitter reuptake
xenobiotic transport
monoamine transport
neurotransmitter uptake
terminal bouton
ammonium transport
synaptic vesicle membrane
synaptic vesicle cycle
vesicle-mediated transport in synapse
organic hydroxy compound transport
drug transport
neurotransmitter transport
regulation of neurotransmitter levels
cell junction
import into cell
cation transport
endoplasmic reticulum membrane
response to drug
transmembrane transport
ion transport
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport