SLC18A2

Entrez Summary: N/A
UniProt Summary: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sugar tr
MFS 1

sequestering of neurotransmitter
serotonin uptake
serotonin:sodium symporter activity
aminergic neurotransmitter loading into synaptic vesicle
clathrin-sculpted monoamine transport vesicle membrane
monoamine transmembrane transporter activity
serotonin transport
amine transport
neurotransmitter loading into synaptic vesicle
dopamine transport
dopaminergic synapse
catecholamine transport
neurotransmitter reuptake
monoamine transport
negative regulation of reactive oxygen species biosynthetic process
neurotransmitter uptake
response to amphetamine
response to amine
terminal bouton
response to bronchodilator
ammonium transport
negative regulation of reactive oxygen species metabolic process
synaptic vesicle membrane
regulation of reactive oxygen species biosynthetic process
post-embryonic development
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
organic hydroxy compound transport
drug transport
maintenance of location
signal release
regulation of reactive oxygen species metabolic process
neurotransmitter transport
locomotory behavior
response to xenobiotic stimulus
regulation of neurotransmitter levels
anterograde trans-synaptic signaling