SLC18A3

Entrez Summary: This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in acetylcholine transport into synaptic vesicles. {ECO:0000269|PubMed:8071310}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sugar tr
MFS 1

acetylcholine transmembrane transporter activity
acetate ester transport
clathrin-sculpted acetylcholine transport vesicle membrane
AP-1 adaptor complex
AP-2 adaptor complex
ammonium transmembrane transport
organic cation transport
terminal bouton
ammonium transport
clathrin-coated vesicle membrane
signal release from synapse
neurotransmitter secretion
signal release
neurotransmitter transport
regulation of neurotransmitter levels
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
cation transmembrane transport
cation transport
membrane organization
ion transmembrane transport
secretion by cell
export from cell
cell-cell signaling
secretion
transmembrane transport
ion transport
establishment of localization in cell
nitrogen compound transport