SLC1A1

Gene Information

Official Symbol: SLC1A1
Official Name: solute carrier family 1 member 1
Aliases and Previous Symbols: N/A
Entrez ID: 6505
UniProt: P43005
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010].
UniProt Summary: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15670
Expression level (log2 read counts): -4.14

Expression Distribution

cysteine transmembrane transport
cysteine transmembrane transporter activity
L-aspartate import across plasma membrane
cysteine transport
glutamate:sodium symporter activity
D-aspartate import across plasma membrane
D-aspartate transport
high-affinity glutamate transmembrane transporter activity
D-amino acid transport
sulfur amino acid transport
L-aspartate transmembrane transport
L-glutamate import across plasma membrane
L-glutamate import
glutamate binding
L-glutamate transmembrane transporter activity
amino acid import across plasma membrane
chloride transmembrane transporter activity
L-glutamate transmembrane transport
amino acid import
C4-dicarboxylate transport
positive regulation of heart rate
neurotransmitter uptake
glutamate secretion
neutral amino acid transport
positive regulation of heart contraction
sulfur compound transport
L-alpha-amino acid transmembrane transport
acidic amino acid transport
L-amino acid transport
drug transmembrane transport
positive regulation of blood circulation
amino acid transmembrane transport
dicarboxylic acid transport
acid secretion
recycling endosome membrane
chloride transmembrane transport
regulation of heart rate
import across plasma membrane
chloride transport
inorganic anion transmembrane transport