SLC1A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC1A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6510|6510]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15758|Q15758]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-glutamine import across plasma membrane|
|glutamine secretion|
|glutamine transport|
|L-serine transport|
|L-glutamine transmembrane transporter activity|
|L-serine transmembrane transporter activity|
|serine transport|
|neutral amino acid transmembrane transporter activity|
|amino acid import across plasma membrane|
|amino acid import|
|protein homotrimerization|
|amino acid transmembrane transporter activity|
|neutral amino acid transport|
|symporter activity|
|L-alpha-amino acid transmembrane transport|
|protein trimerization|
|L-amino acid transport|
|drug transmembrane transport|
|virus receptor activity|
|amino acid transmembrane transport|
|acid secretion|
|viral entry into host cell|
|import across plasma membrane|
|melanosome|
|entry into host|
|entry into host cell|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|drug transport|
|interaction with host|
|viral life cycle|
|signaling receptor activity|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|protein homooligomerization|
|organic anion transport|
|protein complex oligomerization|
|anion transport|
|cation transmembrane transport|
|import into cell|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cation transport|
|ion transmembrane transport|
|secretion by cell|
|response to drug|
|export from cell|
|secretion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|protein-containing complex assembly|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.6|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.74|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.7|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.73|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.82|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.85|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.9|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.9|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.91|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.23|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.69|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.447|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A5 Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>