SLC22A9

Entrez Summary: N/A
UniProt Summary: Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes. {ECO:0000269|PubMed:17393504}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.001μM R00 exp3	1.73
SGC0946 7μM R03 exp151	1.83

Sugar tr
MFS 1

short-chain fatty acid transmembrane transporter activity
short-chain fatty acid transport
short-chain fatty acid import
sodium-independent organic anion transport
sodium-independent organic anion transmembrane transporter activity
anion:anion antiporter activity
fatty acid transport
hormone transport
monocarboxylic acid transport
basolateral plasma membrane
anion transmembrane transport
carboxylic acid transport
organic acid transport
lipid transport
lipid localization
organic anion transport
regulation of hormone levels
anion transport
ion transmembrane transport
transmembrane transport
ion transport