SLC24A5

Entrez Summary: This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008].
UniProt Summary: Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). {ECO:0000269|PubMed:16357253, ECO:0000269|PubMed:18166528}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of secondary metabolite biosynthetic process
negative regulation of melanin biosynthetic process
calcium, potassium:sodium antiporter activity
regulation of melanin biosynthetic process
regulation of secondary metabolite biosynthetic process
regulation of secondary metabolic process
melanocyte differentiation
pigment cell differentiation
developmental pigmentation
symporter activity
calcium channel activity
sodium ion transmembrane transport
pigmentation
trans-Golgi network membrane
melanosome
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
trans-Golgi network
calcium ion transmembrane transport
calcium ion transport
anion transmembrane transport
divalent metal ion transport
divalent inorganic cation transport
monovalent inorganic cation transport
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis