SLC25A13

Entrez Summary: This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
UniProt Summary: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO:0000269|PubMed:11566871}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

malate-aspartate shuttle
L-aspartate transmembrane transporter activity
L-aspartate transmembrane transport
aspartate transmembrane transport
L-glutamate transmembrane transporter activity
L-glutamate transmembrane transport
C4-dicarboxylate transport
ATP biosynthetic process
gluconeogenesis
purine ribonucleoside triphosphate biosynthetic process
L-alpha-amino acid transmembrane transport
purine nucleoside triphosphate biosynthetic process
acidic amino acid transport
hexose biosynthetic process
ribonucleoside triphosphate biosynthetic process
monosaccharide biosynthetic process
L-amino acid transport
purine ribonucleoside triphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
drug transmembrane transport
amino acid transmembrane transport
dicarboxylic acid transport
nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
respiratory electron transport chain
glucose metabolic process
amino acid transport
carbohydrate biosynthetic process
organic acid transmembrane transport
carboxylic acid transmembrane transport
purine ribonucleotide biosynthetic process
drug transport
response to calcium ion
hexose metabolic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
cellular respiration
ribose phosphate biosynthetic process