SLC25A18

Entrez Summary: N/A
UniProt Summary: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). {ECO:0000269|PubMed:11897791}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

malate-aspartate shuttle
L-aspartate transmembrane transporter activity
L-aspartate transmembrane transport
aspartate transmembrane transport
L-glutamate transmembrane transporter activity
L-glutamate transmembrane transport
C4-dicarboxylate transport
symporter activity
L-alpha-amino acid transmembrane transport
acidic amino acid transport
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
dicarboxylic acid transport
mitochondrial transmembrane transport
respiratory electron transport chain
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
drug transport
cellular respiration
neurotransmitter transport
electron transport chain
mitochondrial transport
energy derivation by oxidation of organic compounds
anion transmembrane transport
organic acid transport
carboxylic acid transport
mitochondrial inner membrane
generation of precursor metabolites and energy
organic anion transport
anion transport
ion transmembrane transport
oxidation-reduction process
response to drug
transmembrane transport
ion transport
nitrogen compound transport