SLC25A33

Entrez Summary: N/A
UniProt Summary: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278). {ECO:0000269|PubMed:14715278, ECO:0000269|PubMed:17596519, ECO:0000269|PubMed:20453889, ECO:0000269|PubMed:25320081}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondria-nucleus signaling pathway
pyrimidine nucleotide transport
pyrimidine nucleotide import into mitochondrion
pyrimidine nucleotide transmembrane transporter activity
nucleotide transmembrane transport
respiratory chain complex III assembly
cellular response to insulin-like growth factor stimulus
mitochondrial respiratory chain complex III assembly
pyrimidine-containing compound transmembrane transport
mitochondrial transcription
mitochondrial genome maintenance
nucleotide transport
regulation of oxidative phosphorylation
cytochrome complex assembly
mitochondrial RNA metabolic process
regulation of mitochondrial membrane potential
regulation of reactive oxygen species biosynthetic process
mitochondrial transmembrane transport
mitochondrial respiratory chain complex assembly
mitochondrial membrane
regulation of cell cycle arrest
regulation of ATP metabolic process
organophosphate ester transport
mitochondrial gene expression
regulation of generation of precursor metabolites and energy
cellular response to insulin stimulus
positive regulation of cell growth
regulation of reactive oxygen species metabolic process
mitochondrial transport
response to insulin
nucleobase-containing compound transport
positive regulation of growth
cellular response to peptide hormone stimulus
cellular response to peptide
response to peptide hormone
mitochondrial inner membrane
regulation of cell growth
regulation of membrane potential
mitochondrion organization
response to peptide