SLC28A2

Entrez Summary: N/A
UniProt Summary: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
EPZ-5676 30μM R05 exp233	-2.05
Cyclosporin-A 0.8μM R07 exp347	2.06

purine nucleoside transmembrane transporter activity
purine nucleoside transmembrane transport
nucleoside:sodium symporter activity
nucleoside transport
nucleoside transmembrane transporter activity
nucleoside transmembrane transport
purine-containing compound transmembrane transport
carbohydrate derivative transport
nucleobase-containing compound transport
transmembrane transport
integral component of plasma membrane
nitrogen compound transport
membrane