SLC2A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC2A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC2A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 2 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6517|6517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14672|P14672]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC2A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC2A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Insulin-regulated facilitative glucose transporter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of synaptic vesicle budding from presynaptic endocytic zone membrane|
|amylopectin biosynthetic process|
|amylopectin metabolic process|
|glucose import in response to insulin stimulus|
|D-glucose transmembrane transporter activity|
|regulation of synaptic vesicle transport|
|insulin-responsive compartment|
|glucose import|
|glucose transmembrane transporter activity|
|trans-Golgi network transport vesicle|
|regulation of synaptic vesicle endocytosis|
|regulation of synaptic vesicle recycling|
|brown fat cell differentiation|
|vesicle membrane|
|multivesicular body|
|glucose transmembrane transport|
|cellular response to osmotic stress|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|T-tubule|
|sarcoplasmic reticulum|
|clathrin-coated pit|
|clathrin-coated vesicle|
|carbohydrate transport|
|endomembrane system|
|response to osmotic stress|
|presynapse|
|fat cell differentiation|
|regulation of synaptic vesicle cycle|
|response to ethanol|
|cytoplasmic vesicle membrane|
|cellular response to insulin stimulus|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|regulation of endocytosis|
|cellular response to oxygen levels|
|membrane raft|
|response to insulin|
|response to alcohol|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|response to antibiotic|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to peptide|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to peptide hormone|
|external side of plasma membrane|
|response to peptide|
|carbohydrate metabolic process|
|response to toxic substance|
|regulation of vesicle-mediated transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|response to hormone|
|regulation of cellular localization|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|regulation of organelle organization|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cellular response to stress|
|macromolecule biosynthetic process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC2A4 Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>