SLC2A4

Entrez Summary: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008].
UniProt Summary: Insulin-regulated facilitative glucose transporter.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MFS 1
Sugar tr

regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
amylopectin biosynthetic process
amylopectin metabolic process
glucose import in response to insulin stimulus
D-glucose transmembrane transporter activity
regulation of synaptic vesicle transport
insulin-responsive compartment
glucose import
glucose transmembrane transporter activity
trans-Golgi network transport vesicle
regulation of synaptic vesicle endocytosis
regulation of synaptic vesicle recycling
brown fat cell differentiation
vesicle membrane
multivesicular body
glucose transmembrane transport
cellular response to osmotic stress
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
T-tubule
sarcoplasmic reticulum
clathrin-coated pit
clathrin-coated vesicle
carbohydrate transport
endomembrane system
response to osmotic stress
presynapse
fat cell differentiation
regulation of synaptic vesicle cycle
response to ethanol
cytoplasmic vesicle membrane
cellular response to insulin stimulus
glucose homeostasis
carbohydrate homeostasis
cellular response to hypoxia
cellular response to decreased oxygen levels
regulation of endocytosis
cellular response to oxygen levels
membrane raft