SLC39A4

Entrez Summary: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
UniProt Summary: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to zinc ion starvation
response to zinc ion starvation
zinc ion import across plasma membrane
zinc ion transmembrane transporter activity
zinc ion transmembrane transport
zinc ion transport
cellular zinc ion homeostasis
zinc ion homeostasis
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
recycling endosome membrane
import across plasma membrane
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
cellular response to starvation
response to starvation
cellular response to nutrient levels
cytoplasmic vesicle
cellular response to extracellular stimulus
divalent metal ion transport
divalent inorganic cation transport
apical plasma membrane
cellular response to external stimulus
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
response to nutrient levels
response to extracellular stimulus
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis