SLC39A6

Entrez Summary: N/A
UniProt Summary: May act as a zinc-influx transporter. {ECO:0000269|PubMed:12839489}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.95
CoCl2 18μM R07 exp346	3.84

zinc ion import across plasma membrane
zinc ion transmembrane transporter activity
zinc ion transmembrane transport
lamellipodium membrane
zinc ion transport
cellular zinc ion homeostasis
zinc ion homeostasis
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
import across plasma membrane
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
divalent metal ion transport
divalent inorganic cation transport
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
cell surface
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
endoplasmic reticulum
chemical homeostasis
transmembrane transport
ion transport
integral component of plasma membrane
homeostatic process