SLC39A9 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC39A9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC39A9
  * **<color #00a2e8>Official Name</color>**: solute carrier family 39 member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55334|55334]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUM3|Q9NUM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC39A9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC39A9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619116|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a zinc-influx transporter. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zip|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metal ion transmembrane transporter activity|
|zinc ion transport|
|transition metal ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|metal ion transport|
|cation transport|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-5.44|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-4.49|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-4.33|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-4.19|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-4.09|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.77|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.6|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.29|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-3.17|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.72|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.43|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.3|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.17|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.15|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.13|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.87|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.75|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.72|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.71|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.02|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.03|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.03|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:unc50|UNC50]]|0.481|
|[[:human genes:e:entpd4|ENTPD4]]|0.459|
|[[:human genes:g:gdi2|GDI2]]|0.452|
|[[:human genes:a:agfg1|AGFG1]]|0.45|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.445|
|[[:human genes:g:gpr107|GPR107]]|0.43|
|[[:human genes:z:zfat|ZFAT]]|0.42|
|[[:human genes:t:tbc1d22b|TBC1D22B]]|0.412|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.412|
|[[:human genes:w:wdr7|WDR7]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC39A9 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>