SLC40A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC40A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC40A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 40 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30061|30061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP59|Q9NP59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC40A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC40A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604653|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FPN1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spleen trabecula formation|
|iron ion export across plasma membrane|
|regulation of transcription from RNA polymerase II promoter in response to iron|
|ferrous iron transmembrane transporter activity|
|iron ion transmembrane transporter activity|
|multicellular organismal iron ion homeostasis|
|cellular response to iron ion|
|iron ion transmembrane transport|
|trabecula formation|
|response to iron ion|
|spleen development|
|export across plasma membrane|
|peptide hormone binding|
|trabecula morphogenesis|
|lymphocyte homeostasis|
|cellular iron ion homeostasis|
|leukocyte homeostasis|
|iron ion transport|
|iron ion homeostasis|
|endothelium development|
|cellular transition metal ion homeostasis|
|synaptic vesicle|
|transition metal ion transport|
|transition metal ion homeostasis|
|cellular response to metal ion|
|basolateral plasma membrane|
|homeostasis of number of cells|
|cellular response to inorganic substance|
|divalent inorganic cation transport|
|multicellular organismal homeostasis|
|response to metal ion|
|response to inorganic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|ion transmembrane transport|
|animal organ morphogenesis|
|negative regulation of cell death|
|export from cell|
|identical protein binding|
|chemical homeostasis|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.37|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.91|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.77|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.73|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.71|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.77|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9709
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC40A1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>