SLC40A1

Entrez Summary: The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008].
UniProt Summary: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	-2.37
Nicotine 3000μM R08 exp510	-1.91
Metformin 100 to 150μM on day4 R04 exp170	-1.77
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.73
2-Methoxyestradiol 0.55μM R07 exp310	-1.72
YM155 0.0002μM R01 exp61	1.71
Methotrexate 0.01μM R08 exp501	1.77
PFI-3 10μM R03 exp144	1.79
Oligomycin-A 2μM R00 exp25	1.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spleen trabecula formation
iron ion export across plasma membrane
regulation of transcription from RNA polymerase II promoter in response to iron
ferrous iron transmembrane transporter activity
iron ion transmembrane transporter activity
multicellular organismal iron ion homeostasis
cellular response to iron ion
iron ion transmembrane transport
trabecula formation
response to iron ion
spleen development
export across plasma membrane
peptide hormone binding
trabecula morphogenesis
lymphocyte homeostasis
cellular iron ion homeostasis
leukocyte homeostasis
iron ion transport
iron ion homeostasis
endothelium development
cellular transition metal ion homeostasis
synaptic vesicle
transition metal ion transport
transition metal ion homeostasis
cellular response to metal ion
basolateral plasma membrane
homeostasis of number of cells
cellular response to inorganic substance
divalent inorganic cation transport
multicellular organismal homeostasis
response to metal ion
response to inorganic substance
cellular metal ion homeostasis
inorganic cation transmembrane transport
hematopoietic or lymphoid organ development
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis