SLC45A2

Entrez Summary: This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

disaccharide transport
sucrose transport
sucrose:proton symporter activity
oligosaccharide transport
melanin biosynthetic process
melanin metabolic process
melanosome membrane
secondary metabolite biosynthetic process
phenol-containing compound biosynthetic process
developmental pigmentation
pigment biosynthetic process
secondary metabolic process
pigment metabolic process
carbohydrate transport
phenol-containing compound metabolic process
pigmentation
organic hydroxy compound biosynthetic process
visual perception
sensory perception of light stimulus
organic hydroxy compound metabolic process
sensory perception
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
nervous system process
system process
membrane