SLC6A1

Entrez Summary: The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017].
UniProt Summary: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

gamma-aminobutyric acid import
positive regulation of gamma-aminobutyric acid secretion
gamma-aminobutyric acid:sodium symporter activity
response to disaccharide
regulation of gamma-aminobutyric acid secretion
negative regulation of synaptic transmission, GABAergic
response to sucrose
neurotransmitter binding
gamma-aminobutyric acid transport
neurotransmitter reuptake
positive regulation of amino acid transport
amino acid import
response to lead ion
neurotransmitter uptake
regulation of amino acid transport
regulation of synaptic transmission, GABAergic
positive regulation of organic acid transport
positive regulation of amine transport
positive regulation of neurotransmitter transport
integral component of postsynaptic membrane
acidic amino acid transport
positive regulation of anion transport
response to cocaine
regulation of organic acid transport
integral component of presynaptic membrane
negative regulation of synaptic transmission
GABA-ergic synapse
response to anesthetic
regulation of amine transport
regulation of anion transport
response to alkaloid
amino acid transport
response to estradiol
monocarboxylic acid transport
regulation of neurotransmitter transport
learning
response to calcium ion
response to purine-containing compound
response to carbohydrate
neurotransmitter transport