SLC6A14

Entrez Summary: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010].
UniProt Summary: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. {ECO:0000269|PubMed:10446133}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

neurotransmitter:sodium symporter activity
amino acid transmembrane transporter activity
amino acid transmembrane transport
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
vesicle
neurotransmitter transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
cellular amino acid metabolic process
organic anion transport
response to toxic substance
anion transport
carboxylic acid metabolic process
ion transmembrane transport
oxoacid metabolic process
organic acid metabolic process
transmembrane transport
ion transport
small molecule metabolic process
nitrogen compound transport