SLC6A6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC6A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6533|6533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31641|P31641]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186854|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. {ECO:0000269|PubMed:8382624}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|taurine:sodium symporter activity|
|alkanesulfonate transport|
|taurine transport|
|neurotransmitter:sodium symporter activity|
|xenobiotic transport|
|amino acid transmembrane transporter activity|
|sulfur compound transport|
|amino acid transmembrane transport|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|neurotransmitter transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|cellular amino acid metabolic process|
|organic anion transport|
|anion transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.95|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.93|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.87|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.86|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.8|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.77|
|[[:results:exp539|42°C R08 exp539]]|1.73|
|[[:results:exp303|39°C R06 exp303]]|1.86|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A6 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>