SLC7A2

Entrez Summary: The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:9174363}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nitric oxide production involved in inflammatory response
L-arginine transmembrane transporter activity
L-arginine import across plasma membrane
L-lysine transmembrane transporter activity
arginine transmembrane transporter activity
L-ornithine transmembrane transporter activity
L-arginine transmembrane transport
L-lysine transmembrane transport
L-lysine transport
arginine transmembrane transport
L-ornithine transmembrane transport
L-arginine transport
basic amino acid transmembrane transporter activity
ornithine transport
arginine transport
basic amino acid transmembrane transport
nitric oxide biosynthetic process
basic amino acid transport
amino acid import across plasma membrane
production of molecular mediator involved in inflammatory response
nitric oxide metabolic process
reactive nitrogen species metabolic process
amino acid import
reactive oxygen species biosynthetic process
amino acid transmembrane transporter activity
neurotransmitter biosynthetic process
L-alpha-amino acid transmembrane transport
macrophage activation
regulation of macrophage activation
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
neurotransmitter metabolic process
import across plasma membrane
reactive oxygen species metabolic process
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
drug transport
anion transmembrane transport